Progress and Prospects in Domestic Animals and Breeding :a Review of Genomic Copy Number Variations
Cheng Hong;Jiang Yu;College of Animal Science and Technology,Northwest A&F University;
The significant progress of de novo assembly and re-sequencing of agricultural animal genomes, promoted the discovery of abundant genetic variations. Global variations mainly include single nucleotide polymorphisms(SNPs)and copy number variations(CNVs). Unlike SNPs, which have been widely studied and applied as molecular marker in breeding, fewer CNVs have been detected and experimental validated. Therefore, CNVs rarely serve as molecular markers in breeding. However, the proportion of genome variation ascribed to CNVs are far larger than to SNPs. So CNVs may have great impacts on agronomic traits. Recently, CNV is on the cutting edge of the research studies as well as applications in livestock and poultry breeding. In this review, we discuss the research progress of CNV, and its prospects for breeding domestic animals.