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Study on chemical constituents from Re-Du-Ning Injection(Ⅱ)

LI Hai-bo;YU Yang;WANG Zhen-zhong;MEI Yu-dan;QIN Da-peng;LI Lin;XIAO Wei;YAO Xin-sheng;Kanion Pharmaceutical Co., Ltd.;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process;Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University;  
Objective To investigate the chemical constituents from Re-Du-Ning Injection(RDN). Methods The chemical constituents were isolated by chromatography on silica gel, ODS, Sephadex LH-20, and Toyopearl HW-40 columns and reverse phase MPLC and HPLC repeatedly. Their structures were identified by spectral data and physicochemical property. Results Sixteen compounds were isolated and identified as 5-O-caffeoylquinic acid(1), 5-O-caffeoylquinic acid methyl ester(2), 4-O-caffeoylquinic acid(3), 5-O-caffeoylquinic acid methyl ester(4), 4,5-di-O-caffeoylquinic acid(5), 4,5-di-O-caffeoylquinic acid methyl ester(6), 3,5-di-O-caffeoylquinic acid(7), 3,5-di-O-caffeoylquinic acid methyl ester(8), 3,4-di-O-caffeoylquinic acid(9), 3,4-di-O-caffeoylquinic acid methyl ester(10), secologanic acid(11), vogeloside(12), 7-epi-vogeloside(13), E-aldosecologanin(14), Z-aldosecologanin(15), and 5H,8H-pyrano [4,3-d] thiazolo [3,2-a] pyridine-3-carboxylic acid(16). Compounds 1—10 showed high efficiency and low toxicity with antivirus activity against RSV. Conclusion All the isolated compounds are reported from RDN Injection for the first time, and caffeoylquinic acids may be one of antivirus pharmacodynamic material bases of RDN.
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