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Isatin hybrids and their anti-tuberculosis activity

Zhi Xu;Shu Zhang;Chuan Gao;Jing Fan;Feng Zhao;Zao-Sheng Lv;Lian-Shun Feng;Wuhan University of Science and Technology;Pony Testing International Group;WuXi AppTec;Hengshui University;Synthetic and Functional Biomolecules Center, Peking University;  
Tuberculosis(TB) is one of the most common and even fatal infectious diseases known to mankind.Millions of new cases are reported every year over the world,and one-third of the world's population is potentially infected with mycobacteria tuberculosis(MTB).Research to develop novel anti-TB drugs led to the identification of several isatin-based antimycobacterial agents,among which a number of potential candidates displayed excellent antimycobacterial activity and were found to be free of cytotoxicity.This review outlines the advances in the application of isatin hybrids as antimycobacterial agents and the critical aspects of design and structure-activity relationship of these derivatives.
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