Analysis of somatic mutations in membrane proteins of tumor cells
WU Shan-shan;ZHOU Zhan;CHEN Shu-qing;Zhejiang Province Key Laboratory of Anti-Cancer Drug Research,College of Pharmaceutical Sciences,Zhejiang University;
Objective To screen specific mutations on extracellular regions of membrane proteins( extracellular membrane protein mutations) in tumor cells and provide the reference information for target searching in cancer precision medicine. Methods Somatic mutations on extracellular regions of membrane proteins of 7042 tumor samples were collected to screen all specific extracellular membrane protein mutations,and the overall distribution of these mutations were obtained by statistical analysis. Genes,gene site and cancer types occured high frequency of extracellular membrane protein mutations were identified. Results 97193 specific extracellular membrane protein mutations were obtained from 4938362 somatic mutations in 7042 tumor samples( 30 cancer types),the statistical analysis showed that 4347 genes and 65532 sites were involved in these specific mutations. The study further analyzed five genes( MUC16、LRP1B、CSMD3、RYR2、USH2A),one site( 17 ∶37868208) and six cancer types( including colorectal cancer,melanoma,uterine cancer,brain lower grade glioma,lung adenocarcinoma and stomach adenocarcinoma) which occured high frequency of extracellular membrane protein mutations. Conclusion An information library of specific mutations on extracellular regions of membrane proteins was established and the distribution of these specific mutations was obtained which can provide reference information for target detection in targeted cancer therapy and immunological therapy.
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