Isolation and identification of terpenoids from Myrrh
ZHAO Nan;YANG Guo-chun;LI Xin-yu;DENG Ru-zhuo;GAO Wen-hui;LI Zhan-li;HUA Hui-ming;LI Da-hong;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University;Key Laboratory of Structure-Based Drug Design and Discovery( Shenyang Pharmaceutical University) ,Ministry of Education;
The chemical constituents from the CHCl3 extract of Commiphora opobalsamum were isolated and purified by various kind of column chromatography on silica gel,Sephadex LH-20 and ODS,and their structures were elucidated by the physico-chemical characters and the spectroscopic analysis. Twelve compounds were obtained and identified as proximadiol( 1),orientalol E( 2),alismol( 3),guaianediol( 4),( 1( 10) E,2R*,4R*,5S*)-2-methoxy-5-acetoxy-furanogermacr-1( 10)-en-6-one( 5),( 1( 10) E,2R*,4R*)-2- methoxy-8,12-epoxygermacra-1( 10),7,11-trien-6-one( 6),myrrhone( 7),dihydropyrocurzerenone( 8),cycloartane-1α,2α,3β,25-tetrol( 9),cycloartan-24-ene-1α,2α,3β-triol( 10),cycloartan-24-ene-1α,3β-diol( 11),and 29-norlanost-8,24-dien-1α,2α,3β-triol( 12),respectively. Compounds 1- 3 were isolated from Commiphora for the first time. All the isolated compounds were evaluated for their cytotoxicity against the PC-3hunman prostate tumor cell line. Only compounds 10 and 12 exhibited weak cytoxicity with IC50 values of37. 4 μmol·L~(-1),26. 2 μmol·L~(-1),respectively.
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